Preparation and dissolution pattern of Eudragit RS microcapsules containing ketoprofen.

The Study of Piroxicam Dissolution from Eudragit Rs-coated Pellets

The objective of this work was to study the dissolution process from piroxicam pellets, coated with Eudragit RS 30 D by fluidized bed, in order to achieve an enteric release of the drug. The coating product contains a methacrylic copolymer which is insoluble, but permeable. The drug-loaded pellets were prepared by extrusionspheronization using microcrystalline cellulose (Avicel PH 101) as a sph...

Preparation and Characterization of Ketoprofen Nanosuspension for Solubility and Dissolution Velocity Enhancement

Nanosuspension technology has been developed as a promising candidate for efficient delivery of hydrophobic drugs. It could maintain the required crystalline state of the drug with reduced particle size, leading to an increased reporting on dissolution rate and therefore improved bioavailability. In this paper, we report on the preparation of ketoprofen (KTF) nanosuspension by high-pressure hom...

Pectin/chitosan/Eudragit RS mixed-film coating for bimodal drug delivery from theophylline pellets: preparation and evaluation.

Pellets containing theophylline as a model drug and microcrystalline cellulose, in a ratio of 6:4, were prepared by the extrusion-spheronization method. The pellets were coated with Eudragit RS aqueous dispersions, containing various amounts of pectin-chitosan complex and different coating mass gains, using a fluidized-bed apparatus. Twelve formulations were developed, which differed in two fac...

Preparation and Characterization of Novel Microcapsules

Preparation and Properties of Olive Oil Microcapsules

In this paper, microcapsules were produced by complex coacervation using gelatin and acacia as wall materials and olive oil as the core substance. Process parameters, such as the dosage of the crosslinker, concentration of the wall materials, pH Value and the ratio between core and wall materials were analyzed in detail. Moreover, crosslinking degree of wall materials was more important in obta...