Presence of an Established Calcification Marker in Trabecular Meshwork Tissue of Glaucoma Donors
نویسندگان
چکیده
منابع مشابه
Mitochondrial damage in the trabecular meshwork of patients with glaucoma.
OBJECTIVES To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species. METHODS Mitochondrial damage was evaluated analyzing a ...
متن کاملGlycans of the trabecular meshwork in primary open angle glaucoma.
AIMS Glycan expression was compared in glaucomatous trabecular meshwork (TM) and normal TM in order to determine any differences which may reflect pathological changes underlying primary open angle glaucoma (POAG). METHODS Resin embedded TM from trabeculectomy specimens from 15 eyes with POAG and from 12 eyes with normal anterior segments were probed with a panel of biotinylated lectins and a...
متن کاملMorphological variability of the trabecular meshwork in glaucoma patients: implications for non-perforating glaucoma surgery.
BACKGROUND/AIMS Morphological variability of the trabecular meshwork could be of considerable importance for the proper intraoperative outcome of non-perforating antiglaucomatous surgery, such as deep sclerectomy and viscocanalostomy. The aim of this study was therefore to assess qualitative and quantitative characteristics of the trabecular meshwork in glaucoma patients undergoing trabeculecto...
متن کاملUltrastructural Changes in Human Trabecular Meshwork Tissue after Laser Trabeculoplasty
Purpose. To compare morphologic changes in human trabecular meshwork (TM) after selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT). Design. Laboratory evaluation of ex vivo human eye TM after laser trabeculoplasty. Methods. Corneoscleral rims from human cadaver eyes were sectioned and treated with varying powers of either SLT or ALT. Specimens were examined using light ...
متن کاملMatrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process.
PURPOSE The matrix GLA (MGP) gene has been found to be among the 10 most highly expressed genes in the human trabecular meshwork (TM), and its expression is affected by conditions associated with glaucoma. Because MGP protein has been shown to play a key role in inhibiting calcification in cartilage and arterial vessels, MGP's function in human TM was investigated. METHODS Perfused TM tissue ...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2007
ISSN: 1552-5783
DOI: 10.1167/iovs.06-1403