Pressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences

Pressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences

Professional deep-water divers exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is associated with CNS hyperexcitability. We have previously reported that HP augments N-methyl-D-aspartate receptor (NMDAR) synaptic responses, increases neuronal excitability, and potentially causes irreversible neuronal damage. We now report that HP (10.1 M...

NMDA receptor - mediated modulation of excitatory 1

28 29 Activity of neurons in the dorsal motor nucleus of the vagus nerve (DMV) is 30 closely regulated by synaptic input, and regulation of that input by glutamate receptors 31 on presynaptic terminals has been proposed. Presynaptic NMDA receptors have been 32 identified in a number of brain regions and act to modulate neurotransmitter release, but 33 functional presynaptic NMDA receptors have ...

Modulation of NMDA Receptor Activity in Fibromyalgia

Activation of the N-methyl-d-aspartate receptor (NMDAR) results in increased sensitivity of spinal cord and brain pathways that process sensory information, particularly those which relate to pain. The NMDAR shows increased activity in fibromyalgia and hence modulation of the NMDAR is a target for therapeutic intervention. A literature review of interventions impacting on the NMDAR shows a numb...

Principles of NMDA Receptor Allosteric Modulation

NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons.

We studied the action potential-evoked autaptic N-methyl-d-aspartate receptor-mediated excitatory postsynaptic currents (NMDA-EPSCs) using solitary cerebellar neurons cultured in microislands from wild-type (+/+), NR2A subunit knockout (NR2A-/-), and NR2C subunit knockout (NR2C-/-) mice. The peak amplitude of autaptic NMDA-EPSCs increased for all genotypes between days in vitro 8 (DIV8) and DIV...