Prion protein expression modulates neuronal copper content
نویسندگان
چکیده
منابع مشابه
Prion protein expression level alters regional copper, iron and zinc content in the mouse brain.
The central role of the prion protein (PrP) in a family of fatal neurodegenerate diseases has garnered considerable research interest over the past two decades. Moreover, the role of PrP in neuronal development, as well as its apparent role in metal homeostasis, is increasingly of interest. The host-encoded form of the prion protein (PrP(C)) binds multiple copper atoms via its N-terminal domain...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2003
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2003.02046.x