Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium
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چکیده
منابع مشابه
Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons.
We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whole cell recordings in voltage- and current-clamp modes to measure ion currents and changes in membrane potential from isolated canine IC neurons. Whole cell currents from these neurons showed fast- ...
متن کاملDevelopmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system
Early electrical activity and calcium influx regulate crucial aspects of neuronal development. Small-conductance calcium-activated potassium (SK) channels regulate action potential firing and shape calcium influx through feedback regulation in mature neurons. These functions, observed in the adult nervous system, make them ideal candidates to regulate activity- and calcium-dependent processes i...
متن کاملPreferential assembly of heteromeric small conductance calcium-activated potassium channels.
The activation of small conductance calcium-dependent (SK) channels regulates membrane excitability by causing membrane hyperpolarization. Three subtypes (SK1-3) have been cloned, with each subtype expressed within the nervous system. The locations of channel subunits overlap, with SK1 and SK2 subunits often expressed in the same brain region. We showed that expressed homomeric rat SK1 subunits...
متن کاملA human intermediate conductance calcium-activated potassium channel.
An intermediate conductance calcium-activated potassium channel, hIK1, was cloned from human pancreas. The predicted amino acid sequence is related to, but distinct from, the small conductance calcium-activated potassium channel subfamily, which is approximately 50% conserved. hIK1 mRNA was detected in peripheral tissues but not in brain. Expression of hIK1 in Xenopus oocytes gave rise to inwar...
متن کاملSmall-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles.
RATIONALE Fibrillation/defibrillation episodes in failing ventricles may be followed by action potential duration (APD) shortening and recurrent spontaneous ventricular fibrillation (SVF). OBJECTIVE We hypothesized that activation of apamin-sensitive small-conductance Ca(2+)-activated K(+) (SK) channels is responsible for the postshock APD shortening in failing ventricles. METHODS AND RESUL...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2013
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2013.01.033