Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations
نویسندگان
چکیده
منابع مشابه
Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations
The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations in explicit water, an order of magnitude more than in previous simulations. We analyze the correl...
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ژورنال
عنوان ژورنال: mAbs
سال: 2013
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.23651