Probing the geometric constraints of RNA binding via dynamic covalent chemistry

Interactive Reconstruction via Geometric Probing

Geometric probing considers problems of determining a geometric structure or some aspect of that structure from the results of a mathematical or physical measuring device, a probe. A variety of problems from robotics, medical instrumentation, mathematical optimization, integral and computational geometry, graph theory and other areas fit into this paradigm. This paper surveys the field of geome...

Fabrication and Postmodification of Nanoporous Liquid Crystalline Networks via Dynamic Covalent Chemistry

Constructing covalent organic frameworks in water via dynamic covalent bonding

The formation of keto-enamine based crystalline, porous polymers in water is investigated for the first time. Facile access to the Schiff base reaction in water has been exploited to synthesize stable porous structures using the principles of Dynamic Covalent Chemistry (DCC). Most credibly, the water-based Covalent Organic Frameworks (COFs) possess chemical as well as physical properties such a...

Multifunctional periodic mesoporous organosilicas with bridging groups formed via dynamic covalent chemistry.

Imine-containing bridging groups were formed during self-assembly of periodic mesoporous organosilicas by in situ dynamic covalent chemistry of aldehyde and amine groups in the presence of poly(ethylene oxide)-poly(dl-lactic acid-co-glycolic acid)-poly(ethylene oxide) block copolymer in acidic aqueous solutions.

Stimulus-responsive block copolymer nano-objects and hydrogels via dynamic covalent chemistry.

Herein we demonstrate that dynamic covalent chemistry can be used to induce reversible morphological transitions in block copolymer nano-objects and hydrogels. Poly(glycerol monomethacrylate)-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) diblock copolymer nano-objects (vesicles or worms) were prepared via polymerization-induced self-assembly. Addition of 4-carboxyphenylboronic acid (CPBA) lea...