Process signatures in glatiramer acetate synthesis: structural and functional relationships
نویسندگان
چکیده
منابع مشابه
Anaphylaxis to Glatiramer Acetate
Glatiramer acetate (Copaxone, Teva Pharma) and interferon beta are the two only disease-modifying therapies for multiple sclerosis. Glatiramer acetate is known for frequently simulating mild, anaphylactoid reactions while true, IgEmediated allergic reactions have been hardly reported so far. Herein, we report two females suffering from multiple sclerosis who experienced rapidly aggravating hype...
متن کاملStructural-Functional Relationships
As bstract. Renal biopsies in 45 patients with insulin-dependent diabetes mellitus (IDDM) were examined by semiquantitative light microscopy and quantitative electron microscopic stereologic morphometry. In these 14 males and 31 females, aged 13-52 yr, who had had IDDM for 2.5-29 yr there was no strong relationship between either glomerular basement membrane (GBM) thickness or mesangial expansi...
متن کامل[Nicolau syndrome after administration of glatiramer acetate].
Local complications associated with glatiramer acetate are frequent, especially at the injection site. The presence of pain, oedema, and local erythema is almost a given in areas where the drug is administered subcutaneously. However, the presence of cutaneous necrosis should alert doctors to the possibility of impairment of underlying vascular structures. Nicolau syndrome or embolia cutis medi...
متن کاملTherapy with glatiramer acetate for multiple sclerosis.
BACKGROUND Some clinical data have shown that glatiramer acetate (Copaxone), a synthetic amino acid polymer empirically found to suppress experimental allergic encephalomyelitis (EAE), an animal model of MS, might help improve the outcome of patients with multiple sclerosis (MS). OBJECTIVES We performed a Cochrane review of all randomised, placebo-controlled trials of glatiramer acetate in MS...
متن کاملReversible alopecia associated with glatiramer acetate.
W e describe a 42-year-old woman with relapsingremitting multiple sclerosis (MS) who developed alopecia while receiving pharmacotherapy with glatiramer acetate (GA). The patient was diagnosed with relapsing-remitting MS in 1998 based on her clinical presentation, positive surrogate disease markers on magnetic resonance imaging, and the presence of multiple oligoclonal bands in her cerebrospinal...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12416-1