Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo
نویسندگان
چکیده
منابع مشابه
Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo
The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in azurophil granules. Despite decades of search, the mechanisms underlying the posttranslational processing of neutrophil defensins remain unidentified....
متن کاملSystemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma.
BACKGROUND The well-characterised airway inflammatory phenotypes of asthma include eosinophilic, neutrophilic, mixed eosinophilic/neutrophilic and paucigranulocytic asthma, identified based on the proportion of sputum granulocytes. Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic inflammation in the pathogenesis of airway infl...
متن کاملThe neural development of the biological motion processing system does not rely on early visual input.
Naturally occurring sensory deprivation in humans provides a unique opportunity to identify sensitive phases for the development of neuro-cognitive functions. Patients who had experienced a transient period of congenital visual deprivation due to bilateral dense cataracts (congenital cataract, cc) have shown, after visual re-afferentation, deficits in a number of higher visual functions includi...
متن کاملComparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries
Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products. Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) and calprotectin levels in the saliva of preschool children and the association with S-ECC. Methods: ...
متن کاملNeutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium.
Neutrophils have the capacity to accumulate in high numbers in the lung during infection and inflammation. Because they play an important role in host defence against infection, but may also cause tissue injury, these cells are thought to be involved in the pathogenesis of various inflammatory lung disorders, including chronic bronchitis and chronic obstructive pulmonary disease. Neutrophil pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0125483