Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry
نویسندگان
چکیده
منابع مشابه
Post-translational modifications of connexin26 revealed by mass spectrometry.
Gap junctions play important roles in auditory function and skin biology; mutations in the Cx26 (connexin26) gene are the predominant cause of inherited non-syndromic deafness and cause disfiguring skin disorders. Mass spectrometry (MS) was used to identify PTMs (post-translational modifications) of Cx26 and to determine whether they occur at sites of disease-causing mutations. Cx26 was isolate...
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ژورنال
عنوان ژورنال: Methods
سال: 2011
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2011.09.019