Prognostic implications of myocardial work in patients with reduced left ventricular ejection fraction: a preliminary study

Abstract Funding Acknowledgements Type of funding sources: None. Background. Myocardial work (MW) is a new imaging technique to assess left ventricular (LV) systolic function. It incorporates both deformation parameters (global longitudinal strain -GLS-) and loading conditions gives information on global constructive (GCW), wasted (GWW), LV myocardial index (GWI) efficiency (GWE). Purpose. The aim this study was describe the prognostic role MW in predicting major adverse cardiovascular events (MACE) patients with reduced ejection fraction (LVEF), compare it GLS LVEF. Methods. We retrospectively included consecutive from 2012 2019 dilated LVEF < 50% any aetiology. Clinical variables were collected LVEF, evaluated baseline echocardiogram. MACE defined as heart failure (HF) and/or arrhythmia (VA) cardiac arrest all cause death. Results. 99 included, 26 women (26.3%), mean age at diagnosis 57 years (SD 23). Mean 32.5% 10.3). Baseline characteristics are described Table 1. During median follow-up 25 months (IQR 12), 24 recorded (24.4%). Patients had worse parameters: significantly lower MWI (805 ± 360 % vs 638 277 %, p = 0.04) GCW (1116 535 mmHg 874 458 mmHg, 0.05), tendency GWE (83 11 77 16 0.084). Of note, (33 10% 29 9%, 0.123) (-9.99 3.7% -8.8 3.0, 0.170) showed trend but not associated outcomes. This might suggest that stronger predictors than traditional parameters. Conclusions. In including events. EF seem have less implications cohort when compared MW. Our results preliminary larger studies needed order fully understand clinical utility beyond patient GLOBAL EVENTS NO Hypertension, 41 67 0.014 Ischaemic etiology, 14 20 12 0.448 Creatinine, (SD) - mg/dL 0.96 (0.04) 1.11 (0.09) 0.90 0.021 Bblockers, 98 100 97 0.514 Nitrates, 4 13 0 0.025 Diuretics, 65 93 53 0.006 SD standard deviation Figure. Results