Prognostic significance of <i>PTEN</i>, <i>RB1</i> and <i>BRCA2</i> gene loss in patients with localized and locally advanced prostate cancer

Background . Prostate cancer is the most common malignant condition among oncological diseases of genitourinary tract, which occupies second place in male mortality from neoplasms. At same time, population patients with prostate heterogeneous: some patients, disease does not require active treatment, while others it progresses rapidly formation metastatic castration-resistant cancer. Therefore, search for new predictive markers remains relevant. Objective Analysis prognostic significance loss heterozygosity PTEN , RB1 TP53 BRCA1 and BRCA2 genes localized locally advanced Materials methods The study included 52 cancer, 31 (59.6 %) whom had a form (T1-2N0M0), 21 (40.4 - (T3a-bN0/1M0). All underwent radical prostatectomy, followed by genotyping postoperative biopsy specimens to determine genetic alterations studied genes. Detection deletions was carried out using method multiplex ligation-dependent probe amplification. Results In 13 (25.0 specimen detected deletion gene, 6 (11.5 1 (1.9 gene. were more likely have perineural invasion ( p = 0.01) lymph node involvement 0.0003). Deletion gene associated frequent detection high-grade tumors 0.013), cribriform growth component 0.002), periprostatic tissue 0.005). Conclusion promising tool clarifying prognosis disease, future will allow accurately stratify into risk groups biochemical relapse.