PROGNOSTIC VALUE OF NATRIURETIC PEPTIDES IN RISK ASSESSMENT OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH HEART FAILURE AND ATRIAL FIBRILLATION

Background. Increased levels of brain natriuretic peptide (BNP) and the N-terminal fragment (NT-proBNP) in heart failure (HF) indicates atrial ventricular myocardial remodeling. BNP NT- proBNP have great prognostic value patients with HF. However, fibrillation (AF) can affect interpretation NT-proBNP. AF is one most common conditions HF assessing predictive NT-proBNP extremely important clinical practice for AF. Aim. To determine arrhythmias (VA) markers estimate significance VA risk assessment Material methods. Totally, 164 left ejection fraction (LVEF <50%) were included into study. All underwent transthoracic echocardiography using standard echocardiographic positions; 24-hour ECG monitoring to assess types nature VA. determined by enzyme immunoassay (ELISA) venous blood plasma. Results. In group paroxysms non-sustained tachycardia (NSVT) more frequently recorded compared sinus rhythm (48 (52.2%) versus 21 (29.2%); p=0.005). Patients NSVT without larger (LV) sizes LV volumes; differences between LVEF being statistical results. HF, NSVT, significantly higher (298.8 [149; 500.6] pg/mL 152 [145.7; 335.4] pg/mL, p=0.02) (2071.5 [1385; 4652.4] vs. 971 [778.5; 1452] p<0.0001). A significant positive correlation was found level amount per day; there a day. Conclusion. The incidence among rhythm. registered are characterized LA volumes NSVT. concentrations