Programming Bioactive Architectures with Cyclic Peptide Amphiphiles

Self-assembly and applications of biomimetic and bioactive peptide- amphiphiles

Peptide-amphiphiles are amphiphilic structures with a hydrophilic peptide headgroup that incorporates a bioactive sequence and has the potential to form distinct structures, and a hydrophobic tail that serves to align the headgroup, drive self-assembly, and induce secondary and tertiary conformations. In this paper we review the different self-assembled structures of peptide-amphiphiles that ra...

Peptide based amphiphiles.

Extracellular matrix formation in self-assembled minimalistic bioactive hydrogels based on aromatic peptide amphiphiles

The hitherto inconsistency in clinical performance for engineered skin drives the current development of novel cell-scaffolding materials; one challenge is to only extract essential characteristics from the complex native ECM (extracellular matrix) and incorporate them into a scaffold with minimal complexity to support normal cell functions. This study involved small-molecule-based bioactive hy...

Cyclic peptide facial amphiphile preprogrammed to self-assemble into bioactive peptide capsules.

Self-assembled peptide nanostructures have shown great potential as promising biomaterials. Peptides have the advantage of being intrinsically biocompatible materials. Peptides, as self-assembling building blocks, have mostly been designed to have head/tail molecular configuration. Since there is a great deal of interest in the precise control of a self-assembly process, novel building blocks s...

Peptide Amphiphiles in Corneal Tissue Engineering

The increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable a...