Progression of clot waveform analysis

نویسندگان

چکیده

凝固波形解析(clot waveform analysis: CWA)は,プロトロンビン時間(prothrombin time: PT)や活性化部分トロンボプラスチン時間(activated partial thromboplastin APTT)などの凝固時間測定において得られるフィブリン形成に基づく凝固反応から,包括的に凝固能を評価する方法である.古くからトロンボエラストグラムやトロンビン生成試験などと同じく,播種性血管内凝固症候群や血友病など様々な病態における血液凝固能の評価法として用いられてきた.CWAは専用の機器を必要とせず,ルーチン検査のPTやAPTT測定から自動的にデータを取得できるため,臨床検査への活用に期待されている.近年ではPTやAPTTにおけるCWAのみならず,添加する試薬を変えた新たなCWAが開発され,その有用性が報告されている.現在CWAの機能が実装されている自動分析機は限られているが,続々と自動分析機へのCWA機能の実装が進んでおり,今後のますますの普及化と臨床検査法の一つとして確立されることに期待したい.

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ژورنال

عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis

سال: 2023

ISSN: ['0915-7441', '1880-8808']

DOI: https://doi.org/10.2491/jjsth.34.4