Progressive multifocal leukoencephalopathy treated with nivolumab
نویسندگان
چکیده
منابع مشابه
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab.
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection of the central nervous system, developed during treatment with interferon beta-1a and a selective adhesion-molecule blocker, natalizumab. The first PML lesion apparent on magnetic resonance imaging was indistinguishable from a multiple s...
متن کاملEvaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.
BACKGROUND Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients. METHODS We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, C...
متن کاملProgressive Multifocal Leukoencephalopathy
Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...
متن کاملProgressive Multifocal Leukoencephalopathy.
Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts. Once reactivated, JCV infects oligodendrocytes and a...
متن کاملProgressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John C...
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ژورنال
عنوان ژورنال: Journal of NeuroVirology
سال: 2019
ISSN: 1355-0284,1538-2443
DOI: 10.1007/s13365-019-00738-x