Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels

In type 2 diabetes mellitus (DM2), the impaired functions of brain insulin system are associated with weakened transport through blood-brain barrier due to resistance. Insulin deficiency in can be corrected by intranasal administration (II), whose effect may enhanced C-peptide (ICP). this work, we study treating hyperinsulinemic and normoinsulinemic DM2 rats ICP (36 µg/rat/day), II (20 µg/rat/day) ICP+II on metabolic hormonal parameters. DM2, attenuated thyroid hormone restorative effects glucose, insulin, leptin sensitivity. was ineffective, its combination II. Thus, effective restoring parameters normoinsulinemic, but not hyperinsulinemic, DM2.