Prolonged Transient Ischemia Results in Impaired CBF Recovery and Secondary Glutamate Accumulation in Cats
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چکیده
منابع مشابه
Transient Focal Cerebral Ischemia in Cats
Background and Purpose: TA3090 (Clentiazem) has been shown to have cerebrovascular protective properties in three experimental studies. An in vivo investigation was undertaken to determine its effects on pial arteries and cerebral blood flow and its therapeutic value in transient focal cerebral ischemia. Methods: This experiment was divided into two protocols. In the first, 200 or 400 ug/kg per...
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PURPOSE To investigate the response of the retina to an ischemic insult, we measured the levels of glutamate in the vitreous of rabbit eyes. METHODS Ocular ischemia was induced in the vitreous of rabbit eyes by simultaneous ligature of the optic nerve, ciliary arteries, and extraocular muscles for 45 minutes. Contralateral eyes were subjected to a conjunctival peritomy to serve as sham-operat...
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BACKGROUND AND PURPOSE To study the putative role and predictive significance of glutamate elevation in space-occupying ischemic stroke, we investigated the correlation between perfusional disturbances and glutamate alterations in a transient ischemia model in cats that is susceptible to secondary deterioration after reperfusion. METHODS In 10 halothane-anesthetized cats, the left middle cere...
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In a previous study occlusion of a middle cerebral artery (MCA) followed by 48 h of hypothermia (29 degrees) was lethal in 5 of 5 monkeys as compared to only 3 of 9 normothermic animals. The present study extended these observations in monkeys and cats with or without MCA occlusion. In monkeys MCA occlusion plus 48 h of hypothermia was consistently lethal. Without MCA occlusion of 2 of 3 monkey...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1996
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-199603000-00012