Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection
نویسندگان
چکیده
منابع مشابه
Vpr is preferentially targeted by CTL during HIV-1 infection.
The HIV-1 accessory proteins Vpr, Vpu, and Vif are essential for viral replication, and their cytoplasmic production suggests that they should be processed for recognition by CTLs. However, the extent to which these proteins are targeted in natural infection, as well as precise CTL epitopes within them, remains to be defined. In this study, CTL responses against HIV-1 Vpr, Vpu, and Vif were ana...
متن کاملHIV-1 viral protein R (Vpr) & host cellular responses.
During infection of host cells by HIV-1, active host-pathogen interactions take place. The final balance between these interactions determines the efficiency of viral infection and subsequent disease progression. HIV-infected cells respond to viral invasion with various antiviral strategies such as innate, cellular and humoral immune antiviral defense mechanisms. On the other hand, the virus ha...
متن کاملPromiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are cell-encoded cytidine deaminases, some of which, such as APOBEC3G (A3G) and APOBEC3F (A3F), act as potent human immunodeficiency virus type-1 (HIV-1) restriction factors. These proteins require packaging into HIV-1 particles to exert their antiviral activities, but the molecular mechanism by which this ...
متن کاملHIV Vpr: Roles in Viral Replication and Cellular Metabolism
The auxiliary/non-structural proteins of HIVcan be categorized into 2 groups, essential (Tat and Rev) and accessory (Vpr, Vpx, Vif, Vpu, and Nef). HIV replicates competently in vitro in T-cell lines without the need for accessory gene functions (Subbramanian and Cohen, 1994). However, in primary lymphocytes and macrophages, accessory gene products such as Vpr and Vpx contribute to the efficient...
متن کاملYeast perspectives on HIV-1 VPR.
Increasing evidence suggests that HIV-1 viral protein R (Vpr) plays an important role in viral pathogenesis, as its functions are being linked to viral activation, suppression of human immune functions and depletion of human CD4 lymphocytes, which are the major clinical manifestation of AIDS. In vitro, Vpr shows multiple activities both in mammalian and yeast cells, which include nuclear transp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.04.025