Promoter architecture dynamically modulates transcription factor binding and transcriptional output over time
نویسندگان
چکیده
منابع مشابه
Transcriptional Coactivator CBP Facilitates Transcription Initiation and Reinitiation of HTLV-I and Cyclin D2 Promoter
HTLV-I is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Taxi, the major activator of this virus, is a 40- kDa (353 amino acid) phosphoprotein, predominantly localized in the nucleus of the host cell, which functions to trans-activate both viral and cellular promoters. Recently it has been shown that HTLV-I a...
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An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the strength of DNA binding for individual TFs translates into regulatory control, or whether a diff...
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The transcriptional regulation of a eukaryotic gene is specified by the interplay of specific regulatory factors, general transcription factors (GTFs), RNA polymerase II (Pol II), DNA sequence elements, and the chromatin structure of the promoter. The thousands of genes in a eukaryotic cell share a general transcriptional machinery and a common transcriptional pathway (Orphanides et al. 1996). ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.400.2