Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities
نویسندگان
چکیده
منابع مشابه
PIAS proteins promote SUMO-1 conjugation to STAT1.
Signal transducer and activator of transcription 1 (STAT1) is a critical mediator of interferon-gamma (IFN-gamma)-induced transcription that is regulated through posttranslational modifications and through transacting proteins such as protein inhibitor of activated STAT1 (PIAS1). PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation h...
متن کاملSUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage.
Ubiquitin/26S proteasome-dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1-mediated DNA damage. In the current study, we show that treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent modification of the TOP1 by SUMO-1/Smt3p, a ubiquitin-like protein. This conclusion is based on the...
متن کاملSUMO-1 conjugation selectively modulates STAT1-mediated gene responses.
Signal transducers and activators of transcription 1 (STAT1) is a critical mediator of interferon (IFN)-induced gene responses. Recently, STAT1 was found to become modified by small ubiquitin-like modifier 1 (SUMO-1) conjugation at Lys703 through the SUMO E3 ligase function of protein inhibitors of activated STAT (PIAS) proteins. However, the physiologic function of sumoylation in STAT1 is stil...
متن کاملSUMO-1 conjugation in normal and stress conditions in vivo
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متن کاملSUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
Histone deacetylation plays a central role in the regulation of genes linked to virtually all biological processes. This modification reaction is dependent on a family of related histone deacetylases (HDACs), which function as key components of large multiprotein complexes involved in the development of normal and neoplastic cells. The mechanisms regulating HDACs and their roles in such process...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2005
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401704