Prostaglandins and related factors: XIX. Thin-layer chromatography of prostaglandins

Prostaglandins: Gas Chromatography

Metabolism of free (nonesteriRed) arachidonic acid (5,8,11,14-cis-eicosatetraenoic acid) via the cyclooxygenase (COX) pathway produces a cascade of biologically active compounds collectively known as prostaglandins (PGs). These include prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), prostaglandin F2 (PGF2), prostacyclin (PGI2) and thromboxane A2 (TXA2) (Figure 1). The analysis of PGs and rela...

Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38.

The prostaglandins constitute a class of physiologically active compounds with a widespread occurrence in animal tissues (see References 2 and 3). Previous studies have led to the determination of their structures (4-S), and more recent investigations have shown that they can be formed enzymatically from the essential fatty acids (7,8). It was thus shown that in homogenates of vesicular glands ...

Isolation and Identification of Prostaglandins from Human Seminal Plasma. 18. Prostaglandins and Related Factors.

A depressor substance which stimulates smooth muscle was discovered by Goldblatt and von Euler in extracts of human seminal plasma and of the vesicular glands of sheep (1,Z). The active principle, called prostaglandin, wm shown to have acidic properties. Investigations on its occurrence and biological effects were carried out by von Euler (2) and more recently by El&son (3). Two biologically ac...

Eicosanoids: Prostaglandins and Related Agents

Prostaglandins

Knowledge of the structure and synthesis of antibodies (immunoglobulins) has developed to a remarkable degree in the last decade. Distinct classes of immunoglobulin (yG, yM, -yA, yD, yE, and their subgroups) have been identified and shown to consist of fixed numbers of light and heavy polypeptide chains organized in pairs. Each polypeptide has a segment of variable amino acid sequence; the spec...