Prostatic calcification in ochronosis

Alkaptonuric Ochronosis.

Alkaptonuria is an autosomal recessive metabolic disorder characterized by joints and spine involvement, ochronosis and presence of homogentisic acid in urine and its deposition in cartilage, intervertebral disc and other connective tissues, leading to disabling arthritis in elderly individual.

Cutaneous Markers in Ochronosis

Sir, A 40-year-old woman presented with low backache of five-year duration with pain in the knee, shoulder and ankle joints on both sides. On examination she was found to have thickened ear lobule with restricted mobility of pinna [Figure 1]. There was black pigmentation in the palmar aspect of the right index finger [Figure 2]. She also had hyperpigmented plaques with adherent scales in the le...

Achilles tendon enthesopathy in ochronosis.

Total knee arthroplasty in ochronosis

Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ...

Knee osteoarthrosis secondary to ochronosis – clinical case☆☆☆

Alkaptonuria is a rare metabolic disease in which a deficiency of the enzyme homogentisate dioxygenase causes an accumulation of homogentisic acid. Ochronosis consists of excessive deposition of homogentisic acid in the connective tissue and presents as a chestnut brown or black pigmentation. With aging, the accumulation of pigments from homogentisic acid in the joints causes osteoarthrosis. Th...