Proteasome inhibition aggravates tumour necrosis factor-mediated bone resorption
نویسندگان
چکیده
منابع مشابه
Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis.
OBJECTIVE The proteasome inhibitor bortezomib has potent anti-myeloma and bone-protective activity. Recently, bortezomib was shown to directly inhibit osteoclastogenesis. The aim of this study was to analyze the influence and therapeutic effect of bortezomib in a mouse model of inflammatory arthritis. METHODS Heterozygous human tumor necrosis factor α (hTNFα)-transgenic mice and their wild-ty...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2010
ISSN: 0003-4967
DOI: 10.1136/ard.2010.129593d