Protective Effect of Hypericum perforatum Extract on Methotrexate-Induced Osteotoxicity via Reducing Oxidative Stress and MAPK Activity
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چکیده
منابع مشابه
Protective Effect of Hypericum perforatum L. Extract on Hexavalent Chromium Induced Toxicity in Rat Adrenal Gland
JELENA SAVICI1, OANA MARIA BOLDURA1*, CORNEL BALTA2, DIANA BREZOVAN1, FLORIN MUSELIN1, CALIN MIRCU1, CLAUDIA BORZA3, MARILENA MOTOC3, CAMELIA TULCAN1 1Banat University of Agricultural Sciences and Veterinary Medicine King Michael I of Romania Timisoara, 119 Calea Aradului, 300645, Timisoara, Romania 2 Vasile Goldis University of Arad, Institute of Life Sciences, 86 Liviu Rebreanu Str., 310414, ...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولProtective Effects of Hydroalcoholic Extract of Hypericum Perforatum Against Bleomycin-Induced Pulmonary Fibrosis in Rats
BACKGROUND AND OBJECTIVE: Pulmonary fibrosis is a chronic interstitial lung disease caused by parenchymal lung damage due to inflammatory factors and fibrosis. Hypericum perforatum contains various flavonoids with antioxidant properties. This study aimed to evaluate protective effects of hydroalcoholic extract of Hypericum against bleomycin-induced pulmonary fibrosis in rats. METHODS: This empi...
متن کاملModulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice.
The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced ...
متن کاملAntihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats.
OBJECTIVE To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats. METHODS Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to dia...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2020
ISSN: 1811-7775
DOI: 10.3923/ijp.2020.430.436