Protective Effect of Sauchinone on Methamphetamine-Induced Neurotoxicity in Mice
نویسندگان
چکیده
منابع مشابه
Pramipexole protective effect on rotenone induced neurotoxicity in mice
Introduction: Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexole was tried in a new approach where the treatment began in the middle of rotenone course with oral dose 1m...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولProtective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons
The over-expression of α-synuclein is a major factor in the death of dopaminergic neurons in a methamphetamine-induced model of Parkinson's disease. In the present study, α-synuclein knockdown rats were created by injecting α-synuclein-shRNA lentivirus stereotaxically into the right striatum of experimental rats. At 2 weeks post-injection, the rats were injected intraperitoneally with methamphe...
متن کاملRole of microglia in methamphetamine-induced neurotoxicity.
Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury...
متن کاملProtective Effects of Berberine on Bromobenzene-Induced Nephrotoxicity in Mice
Introduction: Bromobenzene is an environmental toxin whose metabolites cause renal toxicity. The mechanism involved in toxicity includes oxidative stress. The aim of this study was to investigate the protective effects of berberine against bromobenzene-induced renal toxicity in male NMRI mice. Materials and Methods: In this experimental study, subjects were divided into five groups. Group I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2012
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.11207sc