Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review
نویسندگان
چکیده
منابع مشابه
A comprehensive review on vitamin D receptor (VDR) gene polymorphism in immune-related diseases with emphasis on dermatologic disorders
There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.
متن کاملAssociation between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma
The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymorphism and asthma. This case-control study was performed on 209 patients, and 200 healthy control...
متن کاملThe IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immunological consequences of the protective IL23R R381Q gene variant in healthy donors. The IL23R R381Q gen...
متن کاملassociation between interleukin-23 receptor r381q gene polymorphism and asthma
the snp (rs11209026, arg381gln, r381q) in the il-23 receptor (il23r) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. we, therefore, investigated the association between il-23 r r381q gene polymorphism and asthma.this case-control study was performed on 209 patients, and 200 healthy controls...
متن کاملRole of Homocysteine in Diseases: A Review
ABSTRACT Cardiovascular disease (CVD) is one of the most important causes of mortality worldwide. Several risk factors have been proposed to be associated with CVD. The main risk factors include family history, smoking, hypertension, history of diabetes, hyperlipidemia and obesity. However, new factors have been recently proposed to be assoc...
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ژورنال
عنوان ژورنال: Journal of Immunotoxicology
سال: 2016
ISSN: 1547-691X,1547-6901
DOI: 10.3109/1547691x.2015.1115448