Protein Degradation or Regulation: Ub the Judge
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Protein Degradation or Regulation: Ub the Judge
Given the central importance of ubiquitin to proteoly-sis, it is somewhat ironic that the first protein shown to The University of Chicago Department of Biochemistry and Molecular Biology be modified by ubiquitin was histone H2A, a polypeptide that is degraded only very slowly in vivo (Goldknopf and 920 East 58th Street Chicago, Illinois 60637 Busch, 1977). In this and more recent examples (see...
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ژورنال
عنوان ژورنال: Cell
سال: 1996
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81058-2