Protein Kinase Cα Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 during Calcium-dependent Stimulation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells
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منابع مشابه
Co-regulation of AS and eNOS phosphorylation by calcium 1 Protein Kinase C α Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 During Calcium-Dependent Stimulation of Endothelial Nitric Oxide Synthase in Vascular Endothelial Cells*
Endothelial nitric oxide synthase (eNOS) utilizes L-arginine as its principal substrate, converting it to L-citrulline and nitric oxide (NO). L-citrulline is recycled to L-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase (AL), providing the substrate arginine for eNOS and NO production in endothelial cells. Together, these three enzymes, eNOS, AS and AL, make...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.378794