Protein Microarray Analysis in Patients With Asthma

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Analysis of Gene Expression, Signaling Pathways, and Interaction Networks of Some Effective Genes in Patients with Asthma in Microarray Studies Using R Software

 Background and purpose: Asthma is a chronic inflammatory disorder of the airways caused by a combination of complex environmental and genetic interactions. There is an incomplete understanding of this mechanism which affect both severity of the disease and how it responds to treatment. Different gene expressions are reported in patients with asthma and healthy controls. Materials and methods:...

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Asthma is on the rise despite intense, ongoing research underscoring the need for new scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an approach involving expression profiling of lung tissue from mice with experimental asthma. Employing asthma models induced by different allergens and protocols, we identified 6.5% of the tested genome whose expre...

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ژورنال

عنوان ژورنال: Chest

سال: 2009

ISSN: 0012-3692

DOI: 10.1378/chest.08-0962