Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity

Prevalent in nature, protein oligomers play critical roles both physiologically and pathologically. The multimeric nature conformational transiency of greatly complicate a more detailed glimpse into the molecular structure as well function. In this minireview, are classified described on basis biological function, toxicity, application. We also define bottlenecks recent oligomer studies further review numerous frontier methods for engineering oligomers. Progress is being made many fronts wide variety applications, grafting highlighted promising robust method engineering. These advances collectively allow design stabilized that bring us one step closer to understanding their functions, range applications.