Protein structure, function, and regulation in biological movement

The Promyelocytic Leukemia Protein, PML, and Its Biological Function

Protein kinase C: structure, function, and regulation.

The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse transduction mechanisms that result in the generation of protein kinase C's activator, diacylglycerol. Signals that stimulate members of the large families of G protein-coupled receptors, tyrosine kinase receptors, or...

Structure, Function and Regulation

The Na/K-ATPase or Na, K-pump utilizes the free energy of hydrolysis of ATP to actively transport Na and K ions across mammalian cell membranes. This function underlies essentially all of mammalian cell physiology. For example, in the kidney the Na, K-pump controls body Na and K balance, extracellular volume and blood pressure. The Na/K-ATPase is the receptor of digitalis steroids used to treat...

The Lipid Transfer Protein StarD7: Structure, Function, and Regulation

The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes Sta...

Insights into G protein structure, function, and regulation.

In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance of homeostasis is dependent on the continual flow and processing of information through a complex network of cells. Moreover, in order for the organism to respond to an ever-changing environment, intercellular signals must be transduced, amplified, and ultimately converted to the appropriate physiological re...