Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms
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چکیده
منابع مشابه
Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms.
Secretory proteins enter the secretory pathway by translocation across the membrane of the endoplasmic reticulum (ER) via a channel formed primarily by the Sec61 protein. Protein translocation is highly temperature dependent in mesophilic organisms. We asked whether the protein translocation machinery of organisms from extremely cold habitats was adapted to function at low temperature and found...
متن کاملProtein Translocation Across the Endoplasmic Reticulum Membrane
Proteins to be secreted from eukaryotic cells are delivered to the extracellular space after trafficking through a secretory pathway composed of several complex intracellular compartments. Secretory proteins are first translocated from the cytosol into the endoplasmic reticulum (ER), after which they travel by vesicular trafficking via various intermediate destinations en route to the plasma me...
متن کاملMechanism of protein translocation across the endoplasmic reticulum membrane.
MECHANISM OF TARGETING............................................................................................ 501 Signal Recognition Particle ...................................................................................... 502 Signal Sequences ............................................................. ............................. ..... ....... 507 SRP Receptor ............ . . .....
متن کاملProtein translocation across the rough endoplasmic reticulum.
The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transp...
متن کاملAn ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane.
The role of nucleotides in providing energy for polypeptide transfer across the endoplasmic reticulum (ER) membrane is still unknown. To address this question, we treated ER-derived mammalian microsomal vesicles with a photoactivatable analogue of ATP, 8-N3ATP. This treatment resulted in a progressive inhibition of translocation activity. Approximately 20 microsomal membrane proteins were label...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2003
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.00597