Proteomic snapshot of breast cancer cell cycle: G1/S transition point

A Proteomic Snapshot of Breast Cancer Cell Cycle: The G1/S Transition Point

SnapShot: Cell-Cycle Regulators I

function Phase S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly)

SnapShot: Cell-Cycle Regulators II

function S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly) X. laevis (clawed Toad) H. sapiens (Human) Cdk-inhibitory kinases Phosphorylate Cdk in active site, blocking activity swe1 Wee1, Mik1 Dwee1, Dmyt1 Wee1, Myt1 Wee1, Myt1 Cdk-activating phosphatases Dephosphorylate inhibitory phosphorylation of Cdk subunit

Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines

Objective(s):Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. But the effect of berberine on breast cancer has not yet been completely studied. In this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. Materials and Methods: The antiproliferative effects of berberine and doxorubicin alone and in ...

Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.

Breast cancer is the most commonly diagnosed cancer in American women. The underlying mechanisms that cause aberrant cell proliferation and tumor growth involve conserved pathways, which include components of the cell cycle machinery. Proto-oncogenes, growth factors, and steroids have been implicated in the pathogenesis of breast cancer. Surgery, local irradiation, and chemotherapy have been th...