Proton block of proton-activated TRPV1 current
نویسندگان
چکیده
منابع مشابه
Proton block of proton-activated TRPV1 current
The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. In the body core, where temperature is usually stable and capsaicin is normally absent, H(+) released in response to ischemia, tissue injury, or inflammation is the best-known endogenous TRPV1 agonist, activating the channel to mediat...
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Multimodal gating is an essential feature of many TRP ion channels, enabling them to respond to complex cellular environments. TRPV1, a pain receptor involved in nociception at the peripheral nerve terminals, can be activated by a range of physical and chemical stimuli (e.g., capsaicin, proton, and heat) and further sensitized by proinflammatory substances. How a single receptor achieves this m...
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The capsaicin receptor TRPV1, a member of the transient receptor potential family of non-selective cation channels is a polymodal nociceptor. Noxious thermal stimuli, protons, and the alkaloid irritant capsaicin open the channel. The mechanisms of heat and capsaicin activation have been linked to voltage-dependent gating in TRPV1. However, until now it was unclear whether proton activation or p...
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The acid titration function of bilayer-incorporated batrachotoxin (BTX)-modified sodium channels was examined in experiments in which the pH was decreased symmetrically, on both sides of the membrane, or asymmetrically, on only one side. In an a t tempt to minimize interpretat ional ambiguities, the experiments were done in 1.0 M NaCI (buffered to the appropr ia te pH) with channels incorporate...
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S our taste can be agreeable in moderation. However, most people respond to drinking lemon juice with a violent contortion of their faces that clearly signals to everybody around that a mouth free of acid is greatly preferred. Such a strong aversive response must be based on a reliable aciddetection system on the tongue. Emily Liman’s Laboratory of Sensory Neurobiology at the University of Sout...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2015
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201511386