PSVIII-B-18 Sustained Maternofetal Inflammation at mid-Gestation Causes Intrauterine Growth Restriction of the Sheep Fetus That is Characterized by Poor Muscle Mass and Asymmetric Body Composition Near Term
نویسندگان
چکیده
Abstract Induction of maternofetal inflammation for two wk at 0.7 gestation was previously shown to cause fetal intrauterine growth restriction (IUGR) in sheep. However, the impact sustained during peak placental development and mid-gestation has not been explored. Therefore, our objective determine effects this period on subsequent growth. Pregnant ewes were injected every 3rd day from 50th 65th d (dGA; term=150 dGA) with saline (control; n=10) or bacterial lipopolysaccharide endotoxin induce IUGR (MI-IUGR; n=12). Fetuses surgically catheterized dGA 118 collect daily blood samples necropsied 125 assess metrics. From 120 125, O2, CO2, HCO3 content less (P < 0.05) MI-IUGR fetuses than controls, but glucose, lactate, pH did differ. Circulating granulocytes platelets greater red cells circulating monocytes, lymphocytes, total leukocytes At necropsy, 23% lighter 0.05), hindlimbs 25% smaller cannon bones 6% shorter compared controls. also had reduced semitendinosus, flexor digitorum superficialis, longissimus dorsi masses Heart, liver, brain differ between control fetuses, brain/bodyweight heart/bodyweight fetuses. We conclude that led hypoxemia (but hypoglycemia), which impaired muscle caused asymmetrical body composition near term. This reflects phenotype other models indicates least partial insufficiency.
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Doppler assessment of the fetus with intrauterine growth restriction.
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Louise C Kenny professor, Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Ireland [email protected] Lesley McCowan professor, Department of Obstetrics and Gynaecology, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand Competing interests: None declared. Provenance and peer review: C...
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ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2022
ISSN: ['0021-8812', '1525-3163', '1525-3015', '1544-7847']
DOI: https://doi.org/10.1093/jas/skac247.568