Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes
نویسندگان
چکیده
منابع مشابه
Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes.
Strain-derived flow of interstitial fluid activates signal transduction pathways in osteocytes that regulate bone mechanical adaptation. Wnts are involved in this process, but whether mechanical loading modulates Wnt signaling in osteocytes is unclear. We assessed whether mechanical stimulation by pulsating fluid flow (PFF) leads to functional Wnt production, and whether nitric oxide (NO) is im...
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The balance between osteoclastic bone resorption and osteoblastic bone formation maintains bone mass, while mechanical loads stimulate bone formation and suppress resorption. The molecular mechanisms responsible for this process have not yet been fully elucidated. In the present study, we assessed whether mechanical stimulation by pulsating fluid flow (PFF) leads to functional Wnt production an...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2009
ISSN: 0736-0266
DOI: 10.1002/jor.20888