Pupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopy

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopy

Wide-field interferometric microscopy techniques have demonstrated their utility in sensing minute changes in the optical path length as well as visualization of sub-diffraction-limited nanoparticles. In this work, we demonstrate enhanced signal levels for nanoparticle detection by pupil function engineering in wide-field common-path interferometric microscopy. We quantify the improvements in n...

متن کامل

Nanoparticle classification in wide-field interferometric microscopy by supervised learning from model.

Interference-enhanced wide-field nanoparticle imaging is a highly sensitive technique that has found numerous applications in labeled and label-free subdiffraction-limited pathogen detection. It also provides unique opportunities for nanoparticle classification upon detection. More specifically, the nanoparticle defocus images result in a particle-specific response that can be of great utility ...

متن کامل

Phase-retrieved pupil functions in wide-field fluorescence microscopy.

Pupil functions are compact and modifiable descriptions of the three-dimensional (3D) imaging properties of wide-field optical systems. The pupil function of a microscope can be computationally estimated from the measured point spread function (PSF) using phase retrieval algorithms. The compaction of a 3D PSF into a 2D pupil function suppresses artefacts and measurement noise without resorting ...

متن کامل

Confocal surface plasmon microscopy with pupil function engineering.

Surface Plasmon microscopy can measure local changes of refractive index on the micron scale. Interferometric plasmon imaging delivers quantitative high spatial resolution sensitive to refractive index. In addition the so called V(z) method allows image contrast to be controlled by varying the sample defocus without substantially degrading spatial resolution. Here, we show how a confocal system...

متن کامل

Quantum enhanced absorption measurement and wide field microscopy

Several proof of principle experiments have demonstrated the advantages of quantum metrology and sensing schemes over classical counterparts, although the present challenge is to overcome the gap between the proof of principles and the real applications. For example, probing and imaging delicate systems using small number of photons with true and significant sensitivity improvement (without pos...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Optica

سال: 2017

ISSN: 2334-2536

DOI: 10.1364/optica.4.000247