Pyramidal cells accumulate chloride at seizure onset
نویسندگان
چکیده
منابع مشابه
Pyramidal cells accumulate chloride at seizure onset.
Seizures are thought to originate from a failure of inhibition to quell hyperactive neural circuits, but the nature of this failure remains unknown. Here we combine high-speed two-photon imaging with electrophysiological recordings to directly evaluate the interaction between populations of interneurons and principal cells during the onset of seizure-like activity in mouse hippocampal slices. B...
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Here we address how dynamics of glutamatergic and GABAergic synaptic input to CA3 pyramidal cells contribute to spontaneous emergence and evolution of recurrent seizure-like events (SLEs) in juvenile (P10-13) rat hippocampal slices bathed in low-[Mg(2+)] artificial cerebrospinal fluid. In field potential recordings from the CA3 pyramidal layer, a short epoch of high-frequency oscillation (HFO; ...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2012
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2012.05.016