Quantification of extracellular volume with cardiac computed tomography in patients with left ventricle dysfunction

Abstract Funding Acknowledgements Type of funding sources: None. Background Myocardial fibrosis (MF) is a common endpoint in the majority pathological mechanisms affecting cardiac muscle, ultimately resulting failure. Cardiovascular magnetic resonance (CMR) with gadolinium-based contrast agent and T1 mapping technique able to deliver non-invasive quantification extracellular volume (ECV) expansion. Recently, ECV estimation computed tomography (ECV-CCT) has been validated setting amyloidosis, showing good agreement ECV-CMR. However, no evidence available last generation single source energy CT scanner clinical context newly diagnosed left ventricular dysfunction. Therefore, aim this study test diagnostic accuracy ECV-CCT for detection MF patients recent diagnosis reduced ventricle ejection fraction (LVEF), having ECV-CMR as reference technique. Methods A consecutive cohort 41 dysfunction (LVEF < 50%) was enrolled. Time interval maximum 30 days present between CCT CMR. segment evaluability each technique, ECV-CCT, regression analysis Bland-Altman were performed. Results Age enrolled 62 ± 11 years, mean LVEF at CMR 35.2 10.7%. Mean total amount administrated iodinated 112.6 22.2 ml, while overall radiation exposure 2.1 1.1 mSv. Out 656 myocardial segments available, (100%) evaluable 640 (97.6%) demonstrated slightly lower values compared both global region-based comparison (all segments, 33.1 8.5% vs 35.5 10.7%, p 0.001). At analysis, strong correlations described r = 0.877, 95%CI: 0.840 0.914). On bias 2.4 (95%CI: −7.8 12.7). Conclusions last-generation feasible accurate. Integration measurement comprehensive evaluation can be performed small increase exposure.