Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis: a pilot study

Abstract Background Deep brain stimulation (DBS) has proved effective for Parkinson’s disease (PD), but the identification of parameters relies on doctors’ subjective judgment patient behavior. Methods Five PD patients performed 10-meter walking tasks under different frequencies. During tests, a wearable functional near-infrared spectroscopy (fNIRS) system was used to measure concentration change oxygenated hemoglobin (△ H b O 2 ) in prefrontal cortex, parietal lobe and occipital lobe. Brain connectivity global efficiency were calculated quantify activities. Results We discovered that both regional all varied with parameters, DBS pattern enabling highest optimal each patient, accordance clinical assessments treatment decision made by doctors. Conclusions Task fNIRS analysis promise quantified objective solution patient-specific optimization treatment. Trial registration Name: Accurate multidisciplinary cooperative diagnosis model disease. Registration number is ChiCTR1900022715. Date April 23, 2019.