Quarternary structure amplification of protein folding differences observed in ‘native’ platelet factor-4
نویسندگان
چکیده
منابع مشابه
Amplification of bacteria-induced platelet activation is triggered by FcgRIIA, integrin aIIbb3, and platelet factor 4
Greifswald, Germany; Zentrum für Innovationskompetenz–Humorale Immunreaktionen bei Kardiovaskulären Erkrankungen, Universitätsmedizin Greifswald, Greifswald, Germany; Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; and Abteilung Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomfors...
متن کاملAmplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.
Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation. We demonstrate a critical role for the immune receptor FcγRIIA, αIIbβ3, and Src and Syk tyrosine kinases in platelet activation by Staphylococcus aureus, Streptococcus sanguinis, Stre...
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Background and Aims: Platelet factor 4 (PF4) or CXCL4 is a member of CXC chemokine family which is stored in alpha granules of platelets. The main function known for PF4 is angiostasis which may contribute to prevent tumor metastasis. This feature is mediated by CXCR3 on the endothelial cells. Our principal aim was to study the apoptosis induction in three cell lines treated with PF4 and obtain...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1995
ISSN: 0014-5793
DOI: 10.1016/0014-5793(94)01384-d