Radically different maxicircle classes within the same kinetoplast: an artefact or a novel feature of the kinetoplast genome?

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Radically different maxicircle classes within the same kinetoplast: an artefact or a novel feature of the kinetoplast genome?

We discuss here some results which suggest that radically different maxicircle classes coexist within the same kinetoplast. These data, although tentative and incomplete, may provide a new outlook on the kinetoplast genome structure and expression.

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Structure of Leishmania minicircle kinetoplast DNA classes.

In a recent paper (5), Noyes et al. discussed a nested-PCRbased approach for identification and analysis of Leishmania kinetoplast DNA (kDNA) minicircle classes using the analysis of minicircle variable-region (VR) restriction profiles. The kDNA of trypanosomatids consists of catenated minicircle (approximately 5 3 10 to 5 3 10 per associate) and maxicircle (20 to 50 per associate) molecules (8...

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ژورنال

عنوان ژورنال: Kinetoplastid Biology and Disease

سال: 2006

ISSN: 1475-9292

DOI: 10.1186/1475-9292-5-5