Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques
نویسندگان
چکیده
منابع مشابه
Molecular imaging of inflammation for detection of vulnerable atheromatous plaques.
Inflammation plays a major pathogenic role in the development of atheromatous plaques and the progression of atherosclerosis. Disruption of the fibrous cap of atheromatous lesions has been shown to lead to acute cardiovascular events. Atheromatous plaque disruption is the mechanism most commonly associated with the occurrence of acute coronary syndrome, i.e unstable angina and acute myocardial ...
متن کاملVulnerable plaques, inflammation and newer imaging modalities.
Currently, inflammation is considered to be the central player in the pathogenesis of atherosclerosis. It leads to the formation of multiple plaques in the arterial beds including coronary vasculature. Recent studies using the latest imaging techniques have shown that in patients with acute coronary syndromes (ACS) multiple plaques are ruptured and have thrombus formation on them. Various facto...
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Coronary artery disease is the result of atherosclerotic changes to the coronary arterial wall, comprising endothelial dysfunction, vascular inflammation and deposition of lipid-rich macrophage foam cells. Certain high-risk atherosclerotic plaques are vulnerable to disruption, leading to rupture, thrombosis and the clinical sequelae of acute coronary syndrome. Though recognised as the gold stan...
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BACKGROUND Inflammation and intraplaque neovascularization are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and their respective value in predicting clinical events are poorly understood. To determine their respective temporal associations, we conducted a comprehensive assessment of inflammation and intraplaque neovascularization in the carotid plaqu...
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Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal events, like myocardial infarction or stroke. Because morphological imaging has limitations in diagnosing vulnerable plaque, molecular imaging has been developed, in particular, the use of nuclear imagi...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2006
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2005.11.049