Randomized controlled trials – mechanistic studies of testosterone and the cardiovascular system
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چکیده
منابع مشابه
Randomized controlled trials – mechanistic studies of testosterone and the cardiovascular system
Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-controlled trials (RCTs) have reported beneficial effects of testosterone therapy on exercise-induced cardiac ischemia in chronic stable angina, functional exercise capacity, maximum oxygen consumption during exercise (VO2max) and muscle strength in chronic heart failure (CHF), shortening of the Q...
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In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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The term observational study describes a wide range of study designs including prospective and retrospective cohort studies, case-control studies, and cross-sectional studies, a defining feature of which is that any intervention studied is determined by clinical practice and not the protocol. Data from large, prospective observational studies provide information about the safety and efficacy of...
متن کاملTestosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
BACKGROUND Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease. METHODS A systematic review and meta-analysis was conducted of placebo-controlled randomized trials of testosterone ther...
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OBJECTIVE To conduct a systematic review and meta-analysis of randomized trials that assessed the effect of testosterone use on cardiovascular events and risk factors in men with different degrees of androgen deficiency. METHODS Librarian-designed search strategies were used to search the MEDLINE (1966 to October 2004), EMBASE (1988 to October 2004), and Cochrane CENTRAL (inception to October...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2018
ISSN: 1008-682X
DOI: 10.4103/aja.aja_6_18