Rare cancer-specific mutations in PIK3CA show gain of function
نویسندگان
چکیده
منابع مشابه
PIK3CA mutations in ovarian cancer.
To the Editor: In the April 15 issue of Clinical Cancer Research, Levine et al. (1) reported the frequent occurrence of somatic mutations in the phosphatidylinositol 3-kinase p110a catalytic subunit gene PIK3CA in breast and ovarian cancer. While their study broadly supports the conclusions of our previous report in these cancer types (2), there are some important differences. We observed a hig...
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15 صفحه اولDetection of PIK3CA Mutations in Breast Cancer Bone Metastases
Background. An important goal of personalized cancer therapy is to tailor specific therapies to the mutational profile of individual patients. However, whole genome sequencing studies have shown that the mutational profiles of cancers evolve over time and often differ between primary and metastatic sites. Activating point mutations in the PIK3CA gene are common in primary breast cancer tumors, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0701005104