Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control

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Lenient versus strict rate control in atrial fibrillation.

At the turn of the century, a spate of randomized, controlled trials (RCTs) compared the 2 main pharmacological options for rhythm management for atrial fibrillation (AF): repeated attempts to restore and maintain sinus rhythm (rhythm control) and controlling the heart rate without any specific attempts to restore and maintain sinus rhythm (rate control) (1). Largely driven by results of the 2 ...

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Lenient versus strict rate control in patients with atrial fibrillation.

BACKGROUND Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. METHODS We randomly assigned 614 patients with...

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Rate Control for Permanent Atrial Fibrillation

A brief history of rate control for atrial fibrillation. The first attempt to control the ventricular rate in a patient with atrial fibrillation (AF) was likely the description by William Withering of a patient whose pulse became “more full and more regular” after the administration of digitalis leaf in 1785 (1). In the 1931 edition of “Diseases of the Heart,” Sir Thomas Lewis (2) wrote that th...

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Rate control in atrial fibrillation.

Untreated atrial fibrillation is usually associated with a rapid, irregular ventricular response and is often accompanied by symptoms including palpitations, fatigue, dyspnea, and dizziness. It is widely accepted that slowing the ventricular response, both at rest and during activity, with the use of drugs that prolong the refractory period of the atrioventricular (AV) node (so-called rate-cont...

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Rate control in atrial fibrillation.

Control of the heart rate (rate control) is central to atrial fibrillation management, even for patients who ultimately require control of the rhythm. We review heart rate control in patients with atrial fibrillation, including the rationale for the intervention, patient selection, and the treatments available. The choice of rate control depends on the symptoms and clinical characteristics of t...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2013

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2012.11.038