Re-identification of individuals in genomic data-sharing beacons via allele inference
نویسندگان
چکیده
منابع مشابه
Privacy Risks from Genomic Data-Sharing Beacons.
The human genetics community needs robust protocols that enable secure sharing of genomic data from participants in genetic research. Beacons are web servers that answer allele-presence queries--such as "Do you have a genome that has a specific nucleotide (e.g., A) at a specific genomic position (e.g., position 11,272 on chromosome 1)?"--with either "yes" or "no." Here, we show that individuals...
متن کاملAllele identification in assembled genomic sequence datasets.
Allelic variation within species provides fundamental insights into the evolution and ecology of organisms, and information about this variation is becoming increasingly available in sequence datasets of multiple and/or outbred individuals. Unfortunately, identifying true allelic variants poses a number of challenges, given the presence of both sequencing errors and alleles from other closely r...
متن کاملGenomic medicine and data sharing
Introduction Effective data sharing does not occur in the UK despite being essential for the delivery of high-quality genomic services to patients across clinical specialities and to optimize advances in genomic medicine. Sources of data Original papers, reviews, guidelines, policy papers and web-resources. Areas of agreement Data sharing for genomic medicine requires appropriate infrastruc...
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The popularity of the Internet has generated an explosion in the number of accessible information sources. In addition, recent advances in wide-area networking have led to a push for a logically-uniied, yet physically distributed, information repository accessible through the internet. The architecture of data resources and sources should be scalable and able to accommodate hundreds and thousan...
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The current emphasis on broad sharing of human genomic data generated in research in order to maximize utility and public benefit is a significant legacy of the Human Genome Project. Concerns about privacy and discrimination have led to policy responses that restrict access to genomic data as the means for protecting research participants. Our research and experience show, however, that a consi...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2018
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bty643