Re: Wu et al.: Wide-field trend-based progression analysis of combined retinal nerve fiber layer and ganglion cell inner plexiform layer thickness (Ophthalmology. 2020;127:1322-1330)

We read the article by Wu et al.1Wu K. Lin C. Lam A.K. al.Wide-field trend-based progression analysis of combined retinal nerve fiber layer and ganglion cell inner plexiform thickness: a new paradigm to improve glaucoma detection.Ophthalmology. 2020; 127: 1322-1330Abstract Full Text PDF PubMed Scopus (5) Google Scholar Attempts use wide-field OCT data for evaluating structural are interesting necessary understanding spatial relationship between peripapillary macular areas. Our group also introduced combination method that integrates (RNFL) cell–inner (GCIPL) guided (GPA) maps (Cirrus HD-OCT software, version 10.0, Carl Zeiss Meditec, Inc) into single image (we refer this map as “wide-field GPA map” or “GPA PanoMap”), which helps us evaluate temporal sequence patterns glaucomatous progression.2Lee W.J. Na K.I. Ha A. al.Combined cell-inner event-based analysis.Am J Ophthalmol. 2018; 196: 65-71Abstract (18) Scholar,3Lee Park K.H. Seong M. Vulnerability zone in optical coherence tomography analysis.Invest Ophthalmol Vis Sci. 61: 56Crossref However, we would like make few comments on authors’ methodology handling offer some suggestions highlighting method's superiority. First, scan covered an area 12 × 9 mm. The actual eyeball is 3-dimensional (3D), but software-generated images 2-dimensional. As widens, becomes more distorted when 2-dimensional projection made. For superimposition compare images, 3D registration processing necessary. To overcome weakness, our self-produced Visual C++, Studio Community software (Version 2015; Microsoft).4Lee Kim Y.J. J.H. al.Changes optic head induced horizontal eye movements.PLoS One. 13e0204069PubMed Have authors considered these technical issues their study? Second, Topcon provides “Trend” function (Differential IMAGEnet, Corporation). In those maps, although algorithm makes modifications superimposition, thickened (presented red) thinned areas blue) mixed displayed. If perfect—theoretically—no will exist patients with glaucoma. Being users ourselves, owing limitations, cannot effectively Cirrus clinical setting. This limitation may be related first issue presented. Looking at representative cases, portions increased thickness were not Only decreased portion was presented thinning rate (?m/year). wondering if there no increase, displayed, what used minimize Third, it seems central conclusion study RNFL–GCIPL (ganglion complex) (TPA) superior existing RNFL GCIPL TPAs because its ability detect early on. advantages do seem mentioned enough.5Lee Y.K. al.Diagnostic using swept-source detection preperimetric perimetric glaucoma.J Glaucoma. 2017; 26: 577-585Crossref (22) wonder any cases visualization conventional methods, analyzed wider area. Although difficult analyze methodologic complexity, they need discussed maximize benefits TPA promote extensive near future. Wide-field Trend-based Progression Analysis Combined Retinal Nerve Fiber Layer Ganglion Cell Inner Plexiform Thickness: A New Paradigm Improve Glaucoma DetectionOphthalmologyVol. 127Issue 10PreviewEvaluation has been centered progressive over parapapillary region and/or macula. investigated (1) whether combining (i.e., RNFL-GCIPL) outperforms GCIPL, (2) eyes RNFL-GCIPL risk visual field (VF) progression. Full-Text ReplyOphthalmologyVol. 128Issue 1PreviewWe thank Dr Lee al interest study.1 well aware cardinal work applying (GPA; Meditec), analysis, changes shown earlier studies,2,3 enabling providing information rates change.