Reactions of Aggregated Mercaptoethanol Treated Gamma Globulin with Rheumatoid Factor Precipitin and Complement Fixation Studies
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منابع مشابه
Interaction of the Rheumatoid Factor with Antigen-antibody Complexes and Aggregated Gamma Globulin
The effect of highly purified rheumatoid factor on the precipitin reactions of various antigen-antibody systems was determined. The amount of nitrogen precipitated was increased over a broad range when the factor was added to ovalbumin, human albumin, or human gamma globulin, and the corresponding rabbit antibodies. In the zone of antigen excess, soluble antigen-antibody complexes were precipit...
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The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantl...
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During the course of experiments to investigate whether the addition of heat-denatured 7S y-globulin to rheumatoid leucocytes would produce transformation of the lymphocytes, an interesting phenomenon was observed. No specific stimulation of the lymphocytes was seen, but intracellular inclusions in neutrophils and macrophages, accompanied by extracellular bodies, were noted after culture of the...
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Serum samples from patients with seropositive rheumatoid arthritis contain an inhibitor of complement mediated inhibition of immune precipitation (CMIP). This inhibitory effect can be produced by the addition of either purified monoclonal or polyclonal IgM rheumatoid factor (RF) to human serum. The specificity of the rheumatoid factor influences the degree of inhibition, and when precipitation ...
متن کاملCharacterization of the "reactant" (gamma Globulin Factor) in the F Ii Precipitin Reaction and the F Ii Tanned Sheep Cell Agglutination Test
The material in gamma globulin ("reactant") which reacts with rheumatoid sera in the F II precipitin and F II tanned sheep cell agglutination tests was concentrated by precipitation with sodium sulfate. The concentrated "reactant" appeared to consist of polydispersed molecular aggregates of gamma globulin with s(20) constants as high as 40, as well as the previously described inhomogeneous aggr...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1968
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780110402